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Search Result For 'antioxidant' , Result Number : 69

Staff Name
Research Area
Mohammed Fayz Mohamed Aboelmatty
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Antioxidant
Mohammed Fayz Mohamed Aboelmatty
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
natural antioxidants
Nasser Mohamed Abdelshafi
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
use Antioxidants material (Enzymatic - non- Enzymatic – bio-stimulants- Humic acid - sea weed extract) to alleviate the harmful effect of stresses
Alsayed Rashad Abdelmegeed
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Egyptian J.Appli. Sci.Vol.6.No.120 p.48-58.1991) 8-Immune Response and Pathogenisity of four commercial Gumboro disease Vaccines. A.M.Hegazy, M.A.Lebdah and S.R. EL-Attar. (Egyptian J.Appli. Sci.Vol7.No.3 p.561-572.1992.) 9-Clinco and Histopathological Studies on Rabbits given Furazolidone. N.M.Edress, M.S.Aboelfotoh, O.T.Bader, S.R. EL-Attar andO.A.Abdallah. (Zagazig Vet.J.Vol.20.No.2, p.196-208, 1992.) 10-Complications Associated with Strangels in EL-Zahraa Arabian horse stud in Cairo. M.Esmat, S.R. EL-Attar, H.A.Mohamed, M.I.Amer and A.M.Selim. (Zagazig Vet.J.Vol.20.No.4, p.607-618, 1992) 11-Experimental Pathologic Studies on the Effect of Certain Antiprotozoal Drugs on Cat fish(Clarias Lazera). S.R.EL-Attar (Egypt.J.Comp.Clin.Path.Vol.5.No.2, 1992.) 12-Pathological Study on Kidney Affections of Camel at Sharkia Province. A.M.Hanafy, M.H.Kadry, A.S.Moursi, S.R.EL-Attar, M.F.Fahmy and A.A.Ali. (Zagazig Vet.J.Vol.21.No.2, p.338-350, 1993.) 13-Experimental Pathologic Studies on the Role of Eosinophils on Bilharzial Cirrhosis in Mice. O.A.Atallal, A.M.Hanafy, S.R.EL-Attar, A.A.Ali, E.A.EL-Desoky and M.H.Mohamed. (Zagazig Vet.J., 1993) 14-Tisuue Alterations Induced by Phospholipase D2 of Corynebacterium Pseudotubercolosis in Rabbits. S.R.EL-Attar, A.A.Kadri and A.M.Atia (Zagazig Vet.J.Vol.23.No.4, p.38-44, 1995.) 15-Studies on the Role of Fish in Transmission of Some Zoonotic Diseases. M.Amine ,O.Amer and S.R.EL-Attar. (Zagazig Vet.J.Vol.21.No.3, p.414-429-, 1993.)- 3 - 16-Toxocological and Pathological Studies on Cinmethyline on Cat Fish (Clarias Lazera). M.Doghim and S.R.EL-Attar. (Zagazig Vet.J.Vol.25.No.4,p.129-137,1997.) 17-Experimental Pathological and Clincopathological studies on Ceftifur Sodium [Excenel] in albino rats S.A.El-Attar,M.O.T Badr and M.S.Abou El-Fetouh Zag.Vet.J.(ISSN.1110-1458) Vol. 25,No.4 (1997) PP 101-113. 18-Pathological Studies on Outbreaks of Acute and Chronic Toxicosis with Aflatoxin B1 in Rabbits. S.R.EL-Attar,M.Nawer,S.Hassona and M.Soliman. (International conferees of rabbit diseases in hot climates.Cairo,Egypt,1998.) 19-Experimental Pathologic Studies on Pesticides and Parasitic Infection in Rabbits. Osman A. Atallah,Abdallah E.Moursi,EL_Sayed R.EL-Attar,Enass A.Desoky and Samia A.K. Moharram. (Alex.J.Vet.Science,Vol.13.No.4.p.473-484,1997.) 20-Exprimental Pathologic Studies on Nitrite Toxicosis in Tilapia Nilotica. S.R.EL-Attar. (Zagazig Vet.J.Vol.25.No.4,p.122-128,1997.) 21-Recurrent Mastocytoma In A Dog. Sayed R. EL-Attar,Ahmed M. Aldawek,Wagdey El-Meshri and Abdelrazzag A.ELMagdoub. (Zagazig Vet.J.Vol.37.No.3,p.138--143,2009.) 22-Pathology of Gout in GrowingLeayers Attributed to High Protein Diet. Ibrahim m.Eldighayes,Mohamed A.Hamid,Sayed R.EL-Attar and Abdelwahab M.Kammon. (XXVI Annual conference of Indian Association of veterinary Pathologists. October 28- 30, 2009.) 23- Pathologic Observations on Sheep and Goat Pox MahirA.G.Kubba¹, Yousef M. Abouzeed² and Sayed R. El-attar- 4 - (Libyan Vet.Med.J Vol.1.No.1, p.182-190, 2010.) 24- Histological Study of Camel Hemal Nodes. Asma M.Elbahi, Mohamed O.Ahmed and ELsayed R.El-Attar. (Libyan Vet.Med.J Vol.1.No.1, p.134-146, 2010) 25-A study on Toxoplasma gondii in mice(Mus musculus) in Tripoli-Libya El-Gomati K.M., Rashed A.M.,El Naas A.S.,Elsaid M.M.A. and EL-Attar S.R. African J.Biol.Sci.,6(2) : 123-126 (2010) ISSN 1687-4870 26-Unilateral Overictomy of Large Teratoma Through Standing flank Laborotomy in a Mare. L.M.Ben Ali,Fathy El Sedadawy and EL Attar S. (Libyan Vet.Med.J Vol.1.No.1,p.206 -216,2010.). 27-Pathology of Spontaneous Tumors in Different Domestic Animals in Libya: Mahir A.G. Kubba, Mohammed Abushhiwa, Seham A. Al-Azreg , Lutfi M. Ben Ali and Al-Sayed R. Al-attar. LVMJ. Vol.3 (December. 2012). 28-Pathological Evidence for a Fatal Nervous Disease in Grouper Fish in Libya. Sayed R. Al-Attar, Mahir Kubba, and Jameela T. Rizgalla. First International Scientific Conference of the Department of Pathology .,Fac.of.Vet.Med.Cairo University..April 25- 27(2013), Cairo Egypt . 29- Comparative Diagnostic Studies on Marek’s Disease in chickens by Use of Histopathology and Molecular Investigation. Abdel Moniem A Ali, El-Sayed RA El-Attar, Mohamed H Mohamed and Heba M Abdel Ghany Zag. Vet. J. (ISSN. 1110-1458) Vol. 42 No.3 (2014) pp.225-241 30-Pathology of Fatal Multi-Organ Impairment in a Rottweiler Dog Mahir AG Kubba, Seham Al-Azreg and Al-Sayed R Al-Attar. Clinical & Experimental . Pathology.Volume 5 • Issue 5(2015) • 1000249 31-Fertility and Reproductive Outcome in Mice Following Trichloroethane (TCE) Exposure.- 5 - M. A. Al-Griw1, S. A. Al-Azreg2, E. M. Bennour3, S. A. M. El-Mahgiubi2, A. R. Al- Attar2, N. M. Salama1, A. Elnfati1. Am. J. Life. Sci. Res. Vol. 3, Issue 4, 293-303, 2015 32-DIAGNOSIS OF BOVINE ANAPLASMA MARGINALE IN NORTH WESTERN LIBYA USING SEROLOGY AND BLOOD FILMEXAMINATION: A COMPARATIVE STUDY L. S. AL-Bassam*, S. O. AL- Garib**, S.R.EL-Attar***, E. Abdunaser and O. E. Abdouslam*** Bas.J.Vet.Res.Vol.14,No.1,2016. ISI Impact Factor:3.461 33- Hypolipidemic and antioxidant activity of the aqueous extract from the uneaten pulp of the fruit from Cordia dichotoma in healthy and hyperlipidemic Wistar albino rats. El-Newary SA1, Sulieman AM2, El-Attar SR3, Sitohy MZ4 Journal of Natural Medicines pp 1-15. 34-Cutaneous squamous cell carcinoma in the lateral abdominal wallof local . S.K. Tmumen S.A. Al-Azreg ,M.H. Abushhiw ,M.A. Alkoly ,E.M. Bennour and S.R. Al-Attar . Open Veterinary Journal, (2016), Vol. 6(2): 139-142. 35-Chondroblastic Osteosarcoma in a Cat: Case Report. Al Sayed R Al Attar, Kubba MA, A Al Azreg Seham and Adwak AA . J Med Surg Pathol, an open access journal(2016). Volume 1 • Issue 4 • 1000137. 36-Pigmented villonodular synovitis (PVNS) in human being and in animals: A review article . Al-Sayed R.Al-Attar* and Seham A Al-Azreg (Under press) 37- Illustrative Pathology for Medical Students.(Human and Veterinary Illustrative Atlas) Dr.sayed attar and Dr.Mahir Kubba.(under press) 38-Survey on the Important Bacterial,Parasitic and Viral diseases of Imported Camels in Libya A research project submitte to the Libyan national research councel. By Abozaid,Y.M.;Al-Azreg,S. and R.El-attar,S.R. 39-Review Article on Immunopathology of Fascioliasis in Domestic animals. S.R.Al-Attar ,1998 40-Contributer in Handbook of General,Special and Specific Pathology for Students of Fac.Vet.Med.Zagazig University,Egypt.2000-2013.
Alsayed Rashad Abdelmegeed
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Hypolipidemic and antioxidant activity of the aqueous extract from the uneaten pulp of the fruit from Cordia dichotoma in healthy and hyperlipidemic Wistar albino rats.
Asra Mohamed Abdelazim Abedallah
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Antioxidant genes
Asmaa Wageh Zaghlol Awad
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Antioxidant Capacity, Lipid-Related Transcript Expression and the Economics of Broiler Chickens Fed Different Levels of Rutin
Dina Mahmoud Ahmed Metwally
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Clinical Efficacy Associated with Enhanced Antioxidant Enzyme Activities of Silver Nanoparticles Biosynthesized Using Moringa oleifera Leaf Extract, Against Cutaneous Leishmaniasis in a Murine Model of Leishmania major
Reda Mohamed Mohamed Abdelaziz
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Antioxidant activity of some natural plants against oxidative damage of some drugs
Shimaa Ibrahim Mohamed Abdallah
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Efficacy of the dehydrated lemon peels on the immunity, enzymatic antioxidant capacity and growth of Nile tilapia (Oreochromis niloticus) and African catfish (Clarias gariepinus)
Shimaa Abdelkreem Ali Hassan
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Assessment of hematological, hepato-renal, antioxidant, and hormonal responses of Clarias gariepinus exposed to sub-lethal concentrations of oxyfluorfen
Shimaa Abdelkreem Ali Hassan
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
The influence of dietary supplementation of cinnamaldehyde and thymol on the growth performance, immunity and antioxidant status of monosex Nile tilapia fingerlings (Oreochromis nilot
Ghada Ibrahiem Abdelrahman Mohamed
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Antioxidant and immunostimulatory effects of ginger and moringa extracts on paracetamol induced hepatic damage in albino rats
Mohamed Elsayed Mohamed Hassan Badawy
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
10. Essam A. Mahmoud , Badawi M. El-Sayed, Yasser H. Mahsoub, Abd elhakeem El-Murr, Ahmed Neamat-Allah (2020): Effect of Chlorella vulgaris enriched diet on growth performance, hematoimmunological responses, antioxidant and transcriptomics profile disorders caused by deltamethrin toxicity in Nile tilapia (Oreochromis niloticus). Fish & Shellfish Immunology, 102: 422-429.
Mohammed Eid Metwaly
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Antioxidants gene expression
Mohammed Metwally Mohamed Metwallie
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
1. Protective effect of N-acetylcysteine on fenitrothion-induced toxicity: The antioxidant status and metabolizing enzymes expression in rats. Ecotoxicology and Environmental Safety. 2019: 17
Mohammed Metwally Mohamed Metwallie
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Comparative Study on Ginger Powder and Ginger Extract Nanoparticles: Effects on Growth, Immune–Antioxidant Status, Tissue Histoarchitecture, and Resistance to Aeromonas hydrophila and Pseudomonas putida Infection in Oreochromis niloticus
Mohammed Metwally Mohamed Metwallie
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Dietary alpha-lipoic acid boosts growth, immune-antioxidant traits, behavior, and transcriptomes of antioxidant, apoptosis, and immune-related genes to combat cold stress in Nile tilapia (Oreochromis niloticus)
Mohammed Metwally Mohamed Metwallie
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Dietary Curcumin Modulating Effect on Performance, Antioxidant Status, and Immune-Related Response of Broiler Chickens Exposed to Imidacloprid Insecticide
Mohammed Metwally Mohamed Metwallie
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Therapeutic efficacy of coriander (Coriandrum sativum) enriched diets in Oreochromis niloticus: effect on hepatic-renal functions, the antioxidant-immune response and resistance to Aeromonas veronii
Mahmoud Ibrahim Mohieeldeen
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Effect of fish meal substitution with dried bovine hemoglobin on the growth, blood hematology, antioxidant activity and related genes expression, and tissue histoarchitecture of Nile tilapia (Oreochromis niloticus)
Heba Hassan hosny
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Ammonia toxicity in Nile tilapia: Potential role of dietary baicalin on biochemical profile, antioxidant status and infla
Heba Hassan hosny
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Dietary sodium alginate effect on growth, digestion, body composition, antioxidant capacity, and mucous immune response in yellowfin sea bream Acanthopagr
Heba Hassan hosny
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Effect of DietaryMoringa oleiferaLeaves Nanoparticles onGrowth Performance, Physiological, Immunological Responses,and Liver Antioxidant Biomarkers in Nile tilapia (Oreochromisniloticus) against Zinc Oxide Nanoparticles Toxicity
Heba Hassan hosny
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Growth, hemato-biochemical, immune-antioxidant response, and gene expression in Nile tilapia (Oreochromis niloticus) received nano iron oxide-incorporated diets
Heba Hassan hosny
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Nano-liposome of thyme essential oil promotes growth performance, antioxidant and immune responses to aeromonad septicemia in Nile tilapia, Oreochromis niloticus, fingerlings
Heba Hassan hosny
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Pseudomonas putida: Sensitivity to Various Antibiotics, Genetic Diversity, Virulence, and Role of Formic Acid to Modulate the Immune-Antioxidant Status of the Challenged Nile tilapia Compared to Carvacrol Oil
Heba Hassan hosny
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Silica Nanoparticle Acute Toxicity onMaleRattus norvegicusDomestica:Ethological Behavior, HematologicalDisorders, Biochemical Analyses,Hepato-Renal Function, andAntioxidant-Immune Response
Heba Hassan hosny
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
The Dietary Effects of Nutmeg (Myristica fragrans) Extract onGrowth, Hematological Parameters, Immunity, AntioxidantStatus, and Disease Resistance of Common Carp (Cyprinuscarpio) againstAeromonas hydrophila
Ahmed Mohamed Saad Mousttafa
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
• The antioxidant and antimicrobial activity of antimicrobial peptides isolated from plants.
Ahmed Mohamed Saad Mousttafa
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Characterization of composition, antioxidant potential and microbial organisms upon submerged Cicer arietinum fermentation
Elsayed Mohamed Abdel Wahed Khalil
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Production of Feta Like Cheese Fortified With Pomegranate and Lemon Peels Extract as Natural Antioxidants
Elsayed Mohamed Abdel Wahed Khalil
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Production of ghee-like product from vegetable oils blend enriched with red onion skin extract as a natural antioxidant
Behery Ahmid Ali Salman
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Sensory evaluation, antioxidant, antimicrobial activities and colour of strawberry nectar enriched with prodigiosin pigment produced from Serratia marcescens
Khaled Mohammed Ali AlMarakby
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Characterization of progesterone profile, physiological responses, milk composition and blood biochemical and hematological indices at the early stage of lactation in goats. Mahmoud S. El-Tarabanya, Tamer M. Abdel-Hamida, Omar A. Ahmed-Faridb, and Khaled M. Al-Marakbyc a Department of Animal Wealth Development, Faculty of Veterinary Medicine, Zagazig University, Sharkia, Egypt. b Physiology department, National Organization for Drug Control and Research (NODCAR), Cairo, Egypt. c Department of Animal production, Faculty of Agriculture, Zagazig University, Sharkia, Egypt. Abstract The aim of this research was to describe the progesterone profile, physiological response, milk composition, and blood chemistry at the early stage (DIM 30-90 days) of lactation (E1:30-50; E2:50-70; E3:70-90 days) in Baladi goats under Egyptian conditions. The serum progesterone level was significantly reduced with the progress of the early lactation period to reach the least concentration (0.24 ng/ml) at the E3 stage of lactation (P=0.001). The daily milk yield was significantly increased with the progress of the lactation to reach the peak at the E2 stage of lactation (P=0.015). The percentage of milk fat was significantly decreased with the progress of the early lactation period (P=0.032). However, the percentages of total solids and SNF were significantly increased in E2 and E3 stages when compared with the E1 stage (P=0.001 and 0.018, respectively). The serum glucose and total antioxidant capacity were considerably reduced with the progress of the lactation period (P=0.047 and 0.039, respectively). In conclusion, Baladi goats showed a decreased serum progesterone level with the progress of the early lactation period and produce milk with a relatively stable protein and lactose contents. Furthermore, Baladi does able to maintain the stability of most blood biochemical parameters during such period.
Abdelaleim Ismail Ibrahim ElSayed
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
antioxidant defense
Olwi Ali Mohamed Hasanien
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
The influences of dietary supplementation of peanut skin powder (Arachis Hypogaea) on growth performance, carcass traits, blood chemistry, antioxidant activity and meat quality of broilers. M. E. Abd El-Hack1a, E. A. Ashour1, Gh. M. Elaraby2, A. O. Osman3 and M. Arif4 Manuscript ID AN16346, Animal Production Science 2016. Website: http://www.publish.csiro.au/AN/justaccepted/AN16346
Lymaa Mohamed Mostafa Elmaghreby
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Fennel and ammi seed extracts modulate antioxidant defence system and alleviate salinity stress in cowpea (Vigna unguiculata).
Lymaa Mohamed Mostafa Elmaghreby
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Treatment of Sweet Pepper with Stress Tolerance-Inducing Compounds Alleviates Salinity Stress Oxidative Damage by Mediating the Physio-Biochemical Activities and Antioxidant Systems.
Amal Amien Mahmoud Elgendy
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Biological studies of medicinal plants e.g. antimicrobial, cytotoxic, antioxidant antinociceptive, antiinflammatory, hepatoprotective and anti gastroulcerogenic activities.
Ahmed Mohamed Ahmed Ommar
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
THE PROTECTIVE ROLE OF α-TOCOPHEROL AS AN ANTIOXIDANT AGAINST 2-NITROPROPANE TOXICITY IN ALBINO RATS
Ashraf Youssef Nasr Mohamed
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Cytoprotective and antioxidant effects of aged garlic extract against adriamycin-induced cardiotoxicity in adult male rats
Ashraf Youssef Nasr Mohamed
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Protective effect of aged garlic extract against the oxidativestress induced by cisplatin on blood cells parameters andhepatic antioxidant enzymes in rats
Rania Saad Mohamed Ramadan
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
The potential role of antioxidants as adjunctive treatment in toxicant exposure in experimental animal studies
Mona Gomaa Mohammed Mohammed Amir
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
oxidant antioxidant theory
Nadya ebasiry Elsayed
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
ABSTRACT Background: Chromium is generated as a waste product from different industries. Its reproductive toxicity has been addressed in many studies that considered oxidative stress the main contributing factor for such toxicity. Selenium is essential for male reproductive health and crucially involved in regulation of cellular redox status. Aim: To elucidate the potential impacts of potassium dichromate (PDC) on the structure of the epididymis, prostate and seminal vesicles and to investigate the efficacy of selenium on counteracting these impacts. Methods: Thirty-six adult male rats were assigned into four groups: control, selenium, PDC, and PDC+selenium. The animals were subjected for a treatment period of four weeks. At the end of experimental period, blood and semen samples, epididymides, prostates and seminal vesicles were collected and processed for biochemical, morphological and immunohistochemical analyses. Results: PDC administration significantly deteriorated sperm parameters and triggered alteration of cellular redox homeostasis, evidenced by increased serum malonaldehyde levels with decreased enzymatic activity of the antioxidants: superoxide dismutase and catalase. Furthermore, PDC significantly unregulated the expression of the serum inflammatory markers; nuclear factor-kappa B (NF-κB), tumor necrosis factor alpha and interleuken-1beta. Microscopically, all the examined tissues of PDC-treated rats displayed deteriorated microarchitecture as well as elevated 8-hydroxy-2-deoxyguanosine and microtubuleassociated protein light chain3 immunoexpression, indicating increased oxidative DNA damage and autophagy activity. Selenium supplements to PDC-treated rats effectively alleviated all the tested parameters. Conclusion: Selenium supplements could effectively mitigate PDC-induced damage of the epididymis, prostate and seminal vesicles through counteracting oxidative stress, and reducing NF-κB activation and excessive autophagy evoked by PDCSELENIUM COULD ALLEVIATE POTASSIUM DICHROMATE-INDUCED EPIDIDYMAL, PROSTATIC AND SEMINAL VESICLE CHANGES IN ADULT RATS: POTENTIAL ROLE OF INHIBITING NF-ΚB PATHWAY
Nadya ebasiry Elsayed
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
ABSTRACT Background: Hyperglycemia associated with the diabetes mellitus (DM) commonly results in structural abnormalities and hyposalivation in the parotid glands. An antioxidant action in a potent multivitamin called Antox (ANX) aids in reducing oxidative stress. Aim of study: The current study examined the role of ANX in preventing complications from diabetes in the parotid gland, as well as its potential mechanisms. Material and methods: 36 rats were randomly divided into six groups; each group contained six rats. Group 1 (Negative (-ve) control): the rats received only regular food and water. Group 2 (vehicle group): rats received a single i.p. dose of citrate buffer as a vehicle. Group 3: rats were given ANX by oral gavage with a polyethylene canula 0.5 mm in a volume not to exceed 0.3 ml/100 gm at a dose of 10 mg/kg/day. Group 4 (Diabetic/ DM): rats received a single i.p. dose of 50 mg/kg of STZ dissolved in citrate buffer. Group 5 (DM+ Insulin): rats received a single i.p. dose of 50 mg/kg of STZ dissolved in citrate buffer and insulin (Mixtard 30/70; Novo Nordisk) 1 U/100 gm once daily subcutaneous (S.C.). Group 6 (DM+ Insulin + ANX): rats received a single i.p. dose of 50 mg/kg of STZ and insulin 1 U/100 gm /day/S.C. then received ANX orally in a dose of 10 mg/kg/day. All medications were given for 4 weeks. Rats were anaesthetized, and the parotid tissues were obtained for biochemical analysis to measure Malondialdehyde (MDA), superoxide dismutase (SOD), reduced glutathione (GSH), and nitric oxide (NO), for Histopathological examination (Hematoxylin and Eosin staining, Masson trichrome stain) and immunohistochemistry using (8-OHdG, α-SMA and BAX). Results: Remarkably, co-administration of ANX with insulin significantly reduced malondialdehyde (MDA) levels and increased expression of 8-hydroxy-2'-deoxyguanosine (8-OHdG) while enhancing the activities of superoxide dismutase (SOD), glutathione peroxidase (GPX), and total antioxidant capacity (TAC). Additionally, compared to the diabetic rat group and the diabetic group receiving insulin, the combination of ANX and insulin resulted in a considerably decreased expression of Bcl-2, Associated X-protein (Bax) and Smooth muscle alphaactin (α-SMA), with significant reduction in interleukin-1beta (IL1β) level in relation to diabetic group. Conclusion: In comparison to insulin administration alone, co-delivery of ANX with insulin throughout diabetes treatment was more effective in preserving the structure and function of the parotid glandHISTOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY ON THE POSSIBLE AMELIORATING EFFECTS OF ANTOX ON THE PAROTID GLAND OF RATS WITH STREPTOZOTOCIN-INDUCED DIABETES MELLITUS TYPE 1
Nadya ebasiry Elsayed
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
BACKGROUND: Gentamicin is widely used broad spectrum aminoglycoside antibiotic. Despite its beneficial effects, gentamicin has considerable nephrotoxic effects. Salicylic acid is a phenolic compound that has anti-inflammatory, analgesic and antipyretic effect. It has also antioxidant activity that can counteract oxidative damages induced by adverse conditions in animals. OBJECTIVES: The work aims to detect the harmful changes in the rat kidney that occur after administration of gentamicin and to determine whether salicylic acid treatment attenuates gentamicin - induced nephrotoxicity. MATERIAL AND METHODS: Fifty healthy adult male Wister albino rats were obtained from the breading animal house, Faculty of Veterinary Medicine, Zagazig University. These animals were divided randomly and equally in to five groups. Each group contains ten rats. Group 1: Included control animals. Group 2: Included salicylic acid-treated animals. Group 3: Included gentamicin-treated animals. Group 4: Included animals treated with salicylic and gentamicin at the same time. Group 5: Included animals treated with gentamicin and remain for recovery. The rats were anesthetized with ether inhalation and sacrificed. The kidneys were removed and processed for light and electron microscopic examination. RESULTS: The histological study revealed that gentamicin causes severe nephrotoxicity. Exposure to gentamicin caused necrosis of tubular epithelial cells. The glomeruli were also affected. On the other hand, salicylic acid administration protected kidney tissue against the nephrotoxic effect caused by gentamicin treatment. Recovery from gentamicin treatment could occur spontaneously but it was slow and incomplete. CONCLUSION: Gentamicin administration leads to harmful changes in the structure of the rat kidney. Spontaneous recovery could occur but it is slow and incomplete. These nephrotoxic changes can be protected by co-therapy with salicylic acid
Nadya ebasiry Elsayed
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
International Immunopharmacology 2023; Volume 115: 109621 Background Ulcerative colitis (UC) is a global inflammatory bowel disease. Aime :This study aimed to assess the effects of icosapent ethyl on acetic acid-induced colitis in rats as well as the underlying mechanisms involved. Methods 36 male Wister rats were equally divided into Six groups: control, UC, mesalamine 100 mg/kg, icosapent 150mg/kg, icosapent 300 mg/kg, and EX527-icosapent 300 mg/kg groups. EXcept for control group, UC was induced by acetic acid instillation into colon. Drugs were administered once daily for one week then under thiopental anaesthesia, colons were excised. Colitis macroscopic and microscopic scores were assessed. A part of colon was homogenized for detection of malondialdehyde (MDA), inerleukin1 (IL-1β), tumor necrosis factor (TNF-α), superoxide dis-mutase (SOD), phosphorylated Akt (pAkt) and caspase 3 levels. Silent information regulator 1 (SIRT1), hemeoxygenase 1 (HO-1), and nuclear factor erythroid 2 (Nrf2) mRNA expressions were detected. Mallory-stained colonic sections were examined for collagen fibres detection. Immunohistochemistry of NF-κB and p53 expressions in colonic sections were assessed. Results There acetic acid induced colitis increments in MDA, IL-1β, TNF-α, and caspase 3 levels while decreased SOD, pAkt, SIRT1, HO-1, and Nrf2 with increased collagen fibres as well as NF- κB and p53. Icosapent decreased macro& microscopic colitis scores, MDA, IL-1β, TNF-α, and caspase 3 levels while increased SOD, pAkt, SIRT1, HO-1, and Nrf2 with decreased collagen fibres as well as NF-κB and p53. The effects of icosapent 300 mg/kg were similar to mesalamine. Icosapent effects were antagonized by EX527. Conclusion Icosapent alleviated acetic acid-induced colitis via its anti-inflammatory, Antioxidant, and anti-apoptotic effects mediated in part by SIRT1 pathway activationIcosapent ethyl alleviates acetic acid-induced ulcerative colitis via modulation of SIRT1 signaling pathway in rats
Nevertyty Mohamed Mahmoud
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
antioxidants
Hany Mohamed Sadiq Musa
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
chronic liver diseases and antioxidants
Ikram Abdelhalim Abdelmoety
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
9. Abdelhaliem, E. (2020). Evaluation of genetic polymorphisms correlated with antioxidant capacity among pollen grains of Capparis spinosa L. accessions. Journal of Genetic Engineering and Biotechnology (JGEB), in press
Ikram Abdelhalim Abdelmoety
- Faculty Research Area On Zu Site
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Abdel Haliem, E. and Al- Huqail, A. A. 2014. Correlation of genetic variation among wild Trigonella foenum-graecum L. accessions with their antioxidant potential status (accepted for publication in Genetic and Molecular Research (GMR), 13 (4): 10464-10481.
Ikram Abdelhalim Abdelmoety
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Abdelhaliem, E. and Al- Huqail, A. A. 2016. Genetic linkage between protein and DNA polymorphisms and antioxidant capacity of Cuminum cyminum L. accessions. Genetics and Molecular Research, 15 (4): gmr.15048916.
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- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Abdelhaliem, E. (2023). Evaluation of genetic polymorphisms correlated with antioxidant capacity among pollen grains of Capparis spinosa L. accessions. Journal of Genetic Engineering and Biotechnology (JGEB), in press
Ikram Abdelhalim Abdelmoety
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
George, N.; Abdelhalim E.; Abdel-haleem M. 2021. GC-MS Identification of Bioactive Compounds in Unripe Solanum nigrum Berries and Assessment of Antioxidant and Anticancer Activities. Lat. Am. J. Pharm. 40 (11): 2702-8
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